Abivax posted maybe the best ulcerative colitis data anyone's seen, then crashed 60% on a cancer signal Adam May argues is statistical noise. We dig into whether $ABVX is now a mispriced takeout: the maintenance efficacy that beat Rinvoq, how the scary "seven cancer cases" collapse to two, the blackbox question, the Crohn's skew, and the part two safety data due within weeks. Then a quick look at Nectar (NKTR), its alopecia areata data, and the Eli Lilly lawsuit.
This episode is sponsored by AlphaSense, and specifically Andrew's upcoming AI webinar with them: breaking down the modern AI stack for investors with Dave Wang (Wall Street Prompts) and Ben Collins (AlphaSense). Goes live June 25. Register here.
Chapters:
00:00 Intro and disclosure (long ABVX and NKTR)
01:03 Sponsor: AlphaSense AI webinar for investors
02:33 The biotech "GOAT" returns
03:33 Abivax setup: induction vs maintenance, the stakes
06:38 The bar: clinical remission and Rinvoq
10:14 Blowout maintenance data, and endoscopic remission that doubles Rinvoq
14:23 The data drops, then a 60% crash
16:31 The cancer scare, taken apart case by case
24:45 Why it's statistical noise: mechanism, clustering, base rates
28:50 Adverse-event capture and the phase 2 safety database
33:57 Bear case: hasn't the market had time to digest this?
38:00 Blackbox or no blackbox, and does it matter at $100
40:32 The Crohn's readout and the skew
45:36 M&A: timing, the new CCO, what Adam wants them to do
47:38 Part two safety data due within weeks
54:46 The cash question: secondary vs sale
57:49 Nectar: strong data, then an unexplained selloff
59:54 The Eli Lilly lawsuit and the jury-trial angle
01:03:26 Ox40 read-through and the Q32 Bio overhang
01:06:07 Most mispriced pick, targets, and the CEO's Cincor parallel
01:12:10 Wrap
Links:
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Production and editing by The Podcast Consultant - https://thepodcastconsultant.com/
Disclosure: Long ABVX and NKTR