How to Build a Successful Company in an Era of Disruption
What happens when a startup becomes a giant—and then has to reinvent itself all over again?In this episode, Martin Casado sits down with Raghu Raghuram (former CEO of VMware) and Jeetu Patel (President and CPO at Cisco) for a deep, tactical conversation on scaling, disruption, and navigating transformation from the inside. They share hard-won lessons from leading two of the most iconic infrastructure companies in tech—through waves like virtualization, cloud, containers, and now AI.They cover:How to keep innovation alive inside large companiesWhy the best companies operate with a founder’s mindset, even without foundersThe difference between selling to buyers vs. practitionersWhy the story is the strategy, and how to tell it at scaleHow Cisco is rebuilding its startup DNA in the age of AIIf you're building or leading through a major tech wave, this episode is a playbook. Timecodes:0:00 Introduction 2:02 Weapons of Mass Disruption: Abstractions, Business Models, and Cloud 5:57 Cisco’s Missed Cloud Wave & Resetting for Innovation 6:39 Operating Like a Startup: Speed, Scale, and Leadership 10:00 Go-to-Market Challenges: Fencing Off Innovation 11:04 Organic vs. Inorganic Growth: Lessons from VMware 12:04 The 10x Rule and Competing with Incumbents 14:39 Structuring for Disruption: Two-Pizza Teams and Ideal Customer Profiles 18:43 Storytelling as Strategy: Galvanizing Large Organizations 19:42 The AI Wave: Consumerization and Infrastructure Demands 25:34 Founders vs. Operators: Leading Transformations 31:47 Product-Led Organizations: From Sales to Product Focus 34:35 The Future of Infrastructure: AI, Market Size, and Vertical Integration 39:34 Timing, Market, Team, Product, Brand, and Scale 41:19 Authenticity, Opportunity, and Final Thoughts Resources:Find Martin on X: https://x.com/martin_casadoFind Raghu on X: https://x.com/raghuraghuramFind Jeetu on X: https://x.com/jpatel41 Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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