Core Memory

• The Company Trying to Reprogram Aging

  First. The news.The bio-tech player New Limit has raised $130 million from just about the fanciest assembly of smart, rich people imaginable. Nat Friedman and Daniel Gross – via NFDG - Kleiner Perkins, Khosla Ventures and Human Capital are there in their corporate forms and Patrick and John Collison, Josh Kushner, Joe Lonsdale and Fred Ehrsam are there as individuals.Over the past four years, New Limit has been trying to identify the right combinations of transcription factors – a certain class of proteins – that can rewind cells and take them back to a younger state. Their work piggybacks on the Nobel Prize winning work of Shinya Yamanaka, and it’s among the most exciting technology in the entire bio-tech field – at least for me. As you’ll hear in this interview, they’ve made massive progress over the past 18 months or so. We’ve talked about transcription factors and related technology with Joe Betts LaCroix from Retro (podcast under the Joe link, and full video episode on Retro here) and with Brian Armstrong, who co-founded New Limit.In this episode, however, we hung out with Jacob Kimmel, another New Limit co-founder, for a real deep dive on transcription factors and New Limit’s approach to taming them. Kimmel is as clear and eloquent as it gets on explaining this technology.This pod might feel different than the usual pods. It comes from a sit down interview we did with Kimmel for an upcoming Core Memory video on New Limit. Still, it’s glorious.The Core Memory podcast is sponsored by the wonderful people at E1 Ventures. Their money and hearts are pure. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

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• A Brain Researcher's Bid to Make Digital Twins of Humans

  Earlier this month, Nature published some of the results from a multi-year effort to better understand the visual cortex of mice.The work took place under the MICrONS effort backed by IARPA (Intelligence Advanced Research Projects Activity), one of the U.S. government’s more exotic research arms. And it represented a ground-breaking attempt to blend cutting-edge techniques in how we analyze brains with artificial intelligence technology.As The New York Times wrote,The researchers zeroed in on a portion of the mouse brain that receives signals from the eyes and reconstructs what the animal sees. In the first stage of the research, the team recorded the activity of neurons in that region as it showed a mouse videos of different landscapes.The researchers then dissected the mouse brain and doused the cubic millimeter with hardening chemicals. Then they shaved off 28,000 slices from the block of tissue, capturing an image of each one. Computers were trained to recognize the outlines of cells in each slice and link the slices together into three-dimensional shapes. All told, the team charted 200,000 neurons and other types of brain cells, along with 523 million neural connections.Andreas Tolias, our guest on today’s podcast, was one of many researchers involved in this effort, and he walked us through MICrONS in detail.Tolias also took us on an exploration of the history and future of brain research and his current passion, which is to represent human brains in digital form. He’s a fascinating man working one of the most fascinating areas of science.This episode was sponsored by the kind people at E1 Ventures. Enjoy! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

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• Coinbase CEO Brian Armstrong on the Evolving Future of Humans

  Coinbase CEO and co-founder Brian Armstrong joins the pod to discuss crypto, crypto, crypto.Well, not really.Everyone asks Armstrong about crypto all the time, so we decided to head in a different direction and focus on his life and his interests around very cutting-edge science. Armstrong, for example, co-founded and backed New Limit, which is working on therapies to reverse the damage of aging. (We’ll have a Core Memory video episode on them soon.)He’s also been on X talking about the Gattaca Stack. This is his vision of the IVF clinic of the future in which people can make eggs from skin cells and do all sorts of gene editing on embryos either to thwart diseases or even give babies some enhancements. And he sees these babies coming to life in artificial wombs.Let’s get weird, y’all. As Coinbase CEO, Armstrong has been to known to generate controversy now and again with some strongly held views on politics in the workplace and on the Feds. The press has not taken kindly to Armstrong at times for said views, and we get into that as well.If you listen to this and need you some more Brian Armstrong, there’s a great documentary on him and Coinbase called Coin.And now on with the show. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

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• Chris Kemp on Astra's Comeback, Rockets and Drones from Space

  If you’ve seen HBO’s Wild, Wild Space or read When the Heavens Went on Sale, then Chris Kemp needs no introduction. Kemp is one of the stars in both works. For the less familiar, Kemp is the co-founder and CEO of Astra Space, a maker of rockets based in Alameda, Calif. For several years now, Astra has been on a quest to create the cheapest, easiest to launch rocket in the market and to turn rocket-making into a mass production affair. The company has enjoyed glorious highs all the way to orbit and lows where it verged on bankruptcy. Over the past year, Kemp and Astra co-founder Adam London took the company private and raised a fresh $80 million as they head toward flying Rocket 4 - their next-generation machine. We have lots more on that story here. In this episode, we get into Astra’s tumultuous journey with Kemp, his disdain for some of my filmmaking choices and the future of rockets. He envisions a world with rocket launch sites in many countries and rockets ferrying things like drones into battles in far-off places in a matter of seconds. As always, you can listen here or via your favorite podcast provider. And we have a YouTube channel with the podcasts and our latest science and tech videos. Leave a review. Like and subscribe. Calm our souls. Most of all - enjoy! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

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  1:12:26
• Dwarkesh Patel Wants People to Learn Things

  We flipped the tables on Dwarkesh Patel this week and turned the podcaster into the podcastee.Over the past few years, Patel has made a name for himself as a stellar interviewer of interesting people. Whether questioning a scientist, historian or tech engineer, Patel always goes deep with the subject and refuses to dumb things down for any audience. This is a blessing in an era of our attention being seized by 30-second blips and bloops on our phones and social apps.Patel had done a particularly excellent job on the AI front. He’s interviewed most of the major players in the AI field as large language models have risen to the fore. To that end, this podcast brings news. Patel and his co-author Gavin Leech are putting out a new book on AI through Stripe Press. Called The Scaling Era: An Oral History of AI, the book is an oral history of the recent AI era.You can buy it in digital form now and later in hardback. (Look at that Stripe Press website, publishers. Know what you’re capable of with some effort.) I received an early copy, and it really is a wonderful way to understand current AI technology and its implications.In this episode, Patel and I, of course, talk AI, but we also delve into his life and sudden rise as a podcasting force. We recorded the program together in Patel’s San Francisco podcasting lair. I enjoyed his beard. You will enjoy the show. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

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