What can we learn from how one medical start-up fooled Silicon Valley and the world? Elizabeth Holmes dropped out of Stanford University at 19 to start Theranos. She promised investors and the public a revolutionary blood diagnosis machine which would be less painful, accessible and affordable than ordinary lab tests. She managed to raise $9 billion in funding. Now the company is worth nothing. Holmes and her business partner may face up to 20 years in prison for fraud. How did she manage to deceive some of the world's cleverest minds - and is there something about start-up culture and the cult of the visionary leader which encourages charlatans? Evan Davis and guests discuss.
Rebecca Jarvis, chief business, economics and technology correspondent, ABC News
Margaret Heffernan, author and entrepreneur
Jos White, entrepreneur and partner, Notion Capital
Producer: Julie Ball
The investment industry - luck or judgement?
You trust financial professionals to grow your long term savings and pension pot. But how do you know if they are investing it wisely? The UK investment industry is awash with complicated terms and conditions, and unclear and sometimes high charges, which can eat into your monetary returns. The woes of star fund manager Neil Woodford, who has temporarily frozen one of his funds to its investors after poor performance, highlights just how complicated an industry it is. Is some clarity starting to emerge? Evan Davis and expert guests look under the bonnet of the UK investment industry.
James Anderson, partner at Baillie Gifford, who jointly manage the Scottish Mortgage Investment Trust
Bella Caridade Ferreira, chief executive and founder of Fundscape
Sean Hagerty, managing director of Vanguard Europe
Producer: Lesley McAlpine
Poundland, Lidl, B&M Bargains and Primark are thriving successes on the High Street, while more mainstream retailers have seen their profits hit. Just how do the discounters keep their prices so low? Keeping the business model simple, supply chains lean and costs down are key parts of the story.
Barry Williams, Managing Director of Poundland
Simon Arora, Chief Executive, B&M Bargains
Catherine Shuttleworth, Chief Executive of Savvy Marketing
Can a sudden change in direction save a new company? Evan Davis and his guests hear stories about the start-up's nightmare: the original product is not selling, and cash is running out. Can changing focus - with a new service or product - pluck success from the jaws of doom? Speaking to entrepreneurs and experts, he learns about how in a range of sectors, from sanitary products to event ticketing, the key is to shift while staying true to the original vision.
Celia Pool, cofounder DAME
Edmund Glover and Nick Stone, FIXR
Ramdane Mir, cofounder Cobbleweb
Commerce and Crime
From Somali pirates who've turned kidnapping into a global enterprise to cybercrime and fraud - the worlds of business and wrongdoing potentially have much in common. Clever criminals build business empires and fraud is sometimes carried out by well paid workers at legitimate companies. What the two worlds can have in common is a pursuit of profit and a series of apparently rational calculations. Evan Davis and guests explore why some bright, talented people try to get rich the wrong way, while others manage to do it within the rules.
Barrister, Sara George, a partner at Sidley Austin LLP
Michael Corrigan, Chief Executive at Prosper 4 - a training and recruitment firm for former prisoners
and Dr Anja Shortland, Reader in Political Economy at King's College, London.