248 épisodes
- In this episode of Denatured, you’ll hear from Lance Alstodt, chairman and CEO at Biorestorative Therapies, and Paul Mieyal, chief business officer at South Rampart Pharma. We explore why pain has remained such a difficult therapeutic area to tackle and one of the biggest unmet needs today, and how non-opioid mechanisms to regenerative therapies could reshape the future of treatment.
Host
Jennifer C. Smith-Parker, Director of Insights, BioSpace
Guests
Lance Alstodt, Chairman & CEO, BioRestorative Therapies
Paul Mieyal, Chief Business Officer, South Rampart Pharma
Disclaimer: The views expressed in this discussion by guests are their own and do not represent those of their organizations. Biogen validates anti-tau approach at AAIC, psychedelics full speed ahead, ATTR-CM shakeup
15/07/2026 | 21 minBiogen’s new data, presented at the Alzheimer's Association International Conference, supports a tau-focused approach to the intractable neurodegenerative disease; psychedelics are back in the news with more positive data from Compass Pathways and final guidance from the FDA; and the ATTR-CM space got a major shakeup with the late-stage failure of AstraZeneca and Ionis’ antisense therapeutic.- In this episode of Denatured, you’ll hear from Jack Crawford, CEO of Demetra, and Magnus Gustavsson, chief commercial officer at NorthX Biologics. We unpack the evolution of cell line development — CHO cells, targeted integration, transposases and the collaboration models speeding biologics from sequence to GMP.
Host
Jennifer C. Smith-Parker, Director of Insights, BioSpace
Guests
Jack Crawford, CEO, Demeetra
Magnus Gustafsson, Chief Commercial Officer, NorthX Biologics
Disclaimer: The views expressed in this discussion by guests are their own and do not represent those of their organizations. Vertex carries M&A uptick into H2, IPOs and VC raises also grow, FDA on pace despite turmoil
08/07/2026 | 17 minA surprising deal from Vertex Pharmaceuticals adds to Big Pharma’s acquisitive streak as Crinetics folds into the cystic fibrosis drugmaker. Meanwhile, IPOs and venture capital raises trend upward, but mostly for derisked companies. Plus, FDA decisions slow only slightly as the hunt for a permanent leader drags on.
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Unravel the business of science with BioSpace. We dive into biopharma's top stories and biggest challenges, whether it’s layoffs, pipeline shake-ups, acquisitions, new FDA approvals or how to regulate AI in drug development.
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