Cell therapy holds immense potential to transform the way we treat conditions in oncology, ophthalmology, autoimmune disorders, and a wide range of other therapeutic areas. But how do these engineered cells work, and how do scientists ensure they are safe and function as intended? In this episode, co-host Danielle Mandikian sits down with Todd McDevitt, Head of Cell Therapy, to discuss how cell therapies operate within the body, the challenges researchers face in this field, and the advancements needed to unlock their full potential for patients.
Read the full text transcript at www.gene.com/stories/cells-at-work
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S6E04: The Power of Digital Twins
Digital twins are virtual models of real-world systems that have been gaining momentum as a powerful tool in drug discovery and development. We touched on this concept last season when we covered computational advancements in drug discovery. Now, we’re taking a deeper dive into the power of digital twins. By leveraging genomics, physical health data, lab results, and other clinical datasets, digital twins allow researchers to model certain diseases, help predict treatment outcomes, and more efficiently optimize dosing strategies for clinical studies. In this episode, co-host Maria Wilson is joined by Iraj Hosseini, Distinguished Scientist and Director, gRED Development Sciences, to explore how digital twins could simulate thousands of "what if" scenarios, paving the way for faster and more patient-centric therapeutic strategies.
Read the full text transcript at www.gene.com/stories/the-power-of-digital-twins
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S6E03: New Frontiers in Cancer
Each season we discuss new, exciting breakthroughs in cancer research. With evolving technologies enhancing how we understand and target the underlying drivers of cancer, the journey to developing more effective and safer therapies is advancing rapidly. In this episode, co-host Danielle Mandikian speaks with first-time guest Jennifer Schutzman, Executive Group Medical Director, Early Clinical Development, and returning guest Fred de Sauvage, Vice President of Research Oncology, about the innovative approaches scientists are taking to redefine cancer care. They discuss the promise of earlier detection and intervention, patient-centered treatment strategies, persistent challenges in the field, and how scientists are working to close the gap on unmet needs in cancer care.
Read the full text transcript at www.gene.com/stories/new-frontiers-in-cancer
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S6E02: AI and the Quest for New Antibiotics
We published our first episode on the threat of antibiotic resistance in 2016, and nearly a decade later, it remains one of the world’s most pressing health crises. Today, with advances in artificial intelligence (AI), the race to develop new antibiotics is evolving. In this episode, co-host Danielle Mandikian sits down with guests Tommaso Biancalani, Distinguished Scientist and Director of Biological Research and AI Development, and Steven Rutherford, Senior Principal Scientist and Director of Infectious Diseases in Research Biology, to share the latest in the fight against antibiotic resistance. Together, they discuss the challenges of antibiotic discovery and development, and how AI could streamline the process of identifying novel antibiotics within the vast, uncharted chemical universe.
Read the full text transcript at www.gene.com/stories/ai-and-the-quest-for-new-antibiotics
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S6E01: Digging Deeper into Obesity
As we kick off season six, we’re diving deeper into one of our most popular topics from last season – our evolving understanding of obesity. In this episode, co-host Maria Wilson unpacks the latest in obesity biology and management with Manu Chakravarthy, Senior Vice President and Global Head of Cardiovascular, Renal and Metabolism Product Development, who discusses the stigma associated with obesity and how thousands of years of human evolution contribute to this chronic condition. While lifestyle, diet and exercise modifications are still essential in addressing the biological factors that drive obesity, they explore how emerging treatments have the potential to rewire the brain’s hunger and satiety signals – offering a more personalized, sustainable approach.
Read the full text transcript at www.gene.com/stories/digging-deeper-into-obesity
From research on cancer vaccines to why we feel pain, scientists are tackling some of the biggest challenges in human biology. Want to find out what they’re working on? Pull up a stool for "Two Scientists Walk Into a Bar." Subscribe below to catch each episode as it goes live.
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