The Underdog Physician Podcast

In this episode of The Underdog Physician Podcast, host Dr. Anish Desai sits down with Dr. Anant Vinjamoori, MD, MBA—Chief Medical Officer at Hims, Founder of Next Generation Medicine, and former CMO of Modern Age.
Dr. Vinjamoori traces his unconventional journey from systems biology bench research and a dual MD/MBA at Harvard to internal medicine residency at Brigham and Women's Hospital. Rather than following traditional clinical tracks, he broke into healthtech as an early product manager at Virta Health, learning how to build, ship, and manage cross-functional stakeholders at scale.
In this wide-ranging conversation, Dr. Vinjamoori breaks down the realities of pioneering direct-to-consumer longevity clinics, why clinical brand and value proposition trump "shiny object" test panels, the nuanced science and regulatory landscape of therapeutic peptides, and how physicians can evaluate advisory opportunities and leverage AI as an operating system.
Key discussion takeaways:
The Non-Traditional Clinical Path: Why transitioning from residency into entry-level healthtech product management taught him the critical operational and execution skills medical training skips.

Building Modern Age: What it was like stepping into the CMO role of a venture-backed longevity pioneer, adopting the mindset of "strong views, held loosely," and avoiding the trap of physician imposter syndrome.

The Longevity Trap: Why scaling longevity care fails when clinics rely on constellations of expensive tests and treatments without an articulated customer identity, clear brand message, or actionable delivery system.

Peptide Therapeutics & Regulation: The cellular mechanisms of peptides (why they "speak the language of the cell" vs. blunt-force pharmaceuticals), the distinction between FDA-approved agents (e.g., GLP-1s, Tesamorelin, Sermorelin) and research-grade compounds, and the aftermath of the 2023 FDA compounding restrictions.

Framework for Startup Advisory: How clinicians should evaluate advisory roles across three pillars—genuine personal interest, economic upside (balancing cash vs. equity and guarding clinical time), and trust/energy with the founding team.

Next Generation Medicine Mentorship: How Dr. Vinjamoori is structuring clinical and business education, AI tooling, and peer networks to de-risk physician transitions into personalized and proactive care.

In this episode, we interview Scott Becker, founder of Becker’s Healthcare and Becker Business Media, about building an industry-leading healthcare media platform and lessons from interviewing thousands of executives. Scott describes starting with a newsletter and conferences as a convening network, then hiring a full-time team funded by his law practice, expanding from surgery centers into orthopedics, spine, and especially hospitals and health systems, and focusing deeply on a few core lines. He explains that enduring leaders are consistent, values-driven, and clear on their “why,” and advises physician entrepreneurs to be niche-, team-, and customer-centric and to build what customers need. Scott discusses major trends including AI’s cascading use cases, improved nurse workforce production, and nontraditional access to care such as GLP-1 prescribing. He offers a nuanced view of private equity, shares the origin of Building Great Businesses, and highlights resilience lessons, routines for deep work, and priorities around family and staying centered.

00:00 Meet Scott Becker
01:18 How Beckers Started
03:13 Scaling With Great People
05:38 Traits Of Enduring Leaders
09:01 Physician Entrepreneur Playbook
12:33 Next Decade In Healthcare
18:26 Private Equity In Medicine
21:55 Writing Building Great Businesses
25:45 Setbacks And Resilience Lessons
30:22 Work Life Portfolio
32:43 Morning Routine Deep Work
35:27 Legacy And Closing Thoughts

On the Underdog Physician podcast, Dr. Carl Smart, a pulmonary and critical care specialist in Charlotte, North Carolina, discusses his journey from being born in Jamaica to studying chemistry at Fordham, attending Temple for medical school, and choosing pulmonary/critical care after reading CHEST and being drawn to ICU innovation and procedures. He explains how private-practice exposure to business plans and the rise of HMOs and corporate medicine led him to start a hospitalist program in the mid-1990s and pursue an MBA at Wake Forest to better understand finance and operations. Smart shares operational lessons on efficiency (including “just-in-time” concepts), his view that generative AI will transform the healthcare value chain while raising job-displacement and regulatory/ethical concerns, and the origins and thesis of Black Pearl Global Investment focused on affordability, access, and outcomes. He emphasizes founder tenacity, strong teams, realistic goals, and learning from failure, describes his intensive daily schedule across clinical and VC work, and outlines a legacy centered on scalable patient impact.

00:00 Guest Introduction
00:35 Redoing the Intro
02:20 Carl’s Origin Story
03:27 Why Pulmonary Critical Care
04:50 Path to Business Leadership
08:14 Why Get an MBA
10:13 Operational Efficiency Lessons
12:04 Generative AI in Healthcare
15:45 Black Pearl Global Investment Thesis
18:29 What VCs Look For
21:15 Founder Advice and AI Reality
23:13 Embracing Failure
24:47 Work Life Integration
26:13 Staying Calm Under Pressure
28:00 Legacy and Closing

On the Underdog Physician podcast, we interview Dr. Timothy Martens, a congenital cardiothoracic surgeon and venture partner, and Alex Tang, a clinical strategy and innovation leader, about their work at Vaark Ventures supporting clinician-led early-stage healthcare startups. Tim recounts shifting from neuroscience and an interest in neurosurgery to cardiac surgery, then gaining commercialization and FDA exposure through stem cell and tissue engineering research at Columbia, later forming Vaark Ventures as a venture studio that evolved into an active angel syndicate with a diverse membership of clinicians, operators, and technical experts. Alex describes moving from clinical practice into administrative and value-based care roles, building practice models, and bringing payer and revenue-cycle perspective to investing. They outline a thesis focused on solving real “pain points” in healthcare, warn against superficial AI buzzwords, emphasize measurable ROI and workflow solutions, and advise founders on timing, committed teams, validated paid pilots, distribution channels, LOIs, and respectful relationship-building. They also discuss value-based care scaling, mentorship, and using disciplined calendar management.

00:00 Welcome and Guests
01:55 Tim Martins Origin
02:58 From Lab to Venture
05:20 Building Vaark Ventures Network
06:42 Alex Tang Journey
09:59 Investment Thesis
13:14 AI and VC Trends
16:42 Founder Advice
19:50 Value Based Care Playbook
26:06 Go To Market Strategy
30:44 Work Life Integration
32:03 Mentorship and Integrity
34:59 Legacy and Closing

Ewelina discusses FinalSpark’s focus on transparency and science communication, including a live lab view on finalspark.com, to reduce fear and resistance to new technology. She explains the advantages of bootstrapping—control and founder freedom—while noting its limits, as FinalSpark currently has a six-person team and is talking to investors, seeking 50 million Swiss francs mainly to hire highly skilled people. She clarifies she is not the founder; the founders are Swiss entrepreneurs Fred Jordan and Martin Kutter, who started the company in 2014 and initially pursued digital AI research but pivoted due to the high energy and server costs, choosing living neurons for energy efficiency. She advises being selective about events, describes an open, idea-friendly leadership style shaped partly by cultural lessons from the Netherlands and UK, outlines her remote, meeting-batched work routine, and recommends scientists entering entrepreneurship learn psychology.

00:00 Lab Transparency Tour
19:13 Why Clarity Matters
19:40 Bootstrapping vs Investors
21:08 Founders and Early Vision
21:46 Energy Problem to Neurons
22:38 Networking and Events
23:40 Leadership Across Cultures
25:26 Remote Work Routine
27:10 Advice for STEM Founders
27:55 Closure