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TBPN

John Coogan & Jordi Hays
TBPN
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  • Ilya Sutskever on Dwarkesh Patel Reaction, NVIDIA’s Response to Google’s AI Progress, Trump Unveils Genesis | Diet TBPN
    Our favorite moments from today's show, in under 30 minutes. TBPN.com is made possible by: Ramp - https://ramp.comFigma - https://figma.comVanta - https://vanta.comLinear - https://linear.appEight Sleep - https://eightsleep.com/tbpnWander - https://wander.com/tbpnPublic - https://public.comAdQuick - https://adquick.comBezel - https://getbezel.com Numeral - https://www.numeralhq.comPolymarket - https://polymarket.comAttio - https://attio.com/tbpnFin - https://fin.ai/tbpnGraphite - https://graphite.devRestream - https://restream.ioProfound - https://tryprofound.comJulius AI - https://julius.aiturbopuffer - https://turbopuffer.comfal - https://fal.aiPrivy - https://privy.ioCognition - https://cognition.aiGemini - https://gemini.google.comFollow TBPN: https://TBPN.comhttps://x.com/tbpnhttps://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231https://podcasts.apple.com/us/podcast/technology-brothers/id1772360235https://www.youtube.com/@TBPNLive
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  • Crémieux & Kian on Nucleus Genomics, Michael Kratsios on Genesis, Nvidia Responds to TPU Progress | Kian Sadeghi, Joe Weisenthal, Sebastian Siemiatkowski, David Faugno, Keller Rinaudo, Royce Branning
    (01:53) - 𝕏 Timeline Reactions (13:14) - Nvidia Responds to TPU Sales (22:15) - Trump Launches Genesis (25:40) - Trait-Based Embryo Selection Ethics Breakdown (45:17) - Cremieux, a critic of Nucleus Genomics' embryo selection product, discusses the company's misleading claims about their technology's capabilities, particularly in predicting complex traits like intelligence and appearance. He highlights the scientific implausibility of their assertions, noting that their methods cannot reliably predict such traits, and expresses concern over the ethical implications of offering parents a false sense of control over their future children's genetics. Cremieux also points out the potential harm in promoting a product that lacks scientific validation, emphasizing the need for transparency and accuracy in genetic testing services. (01:05:01) - Kian Sadeghi, founder and CEO of Nucleus, a company specializing in consumer genetic testing and analysis, discusses the transparency and accessibility of Nucleus's scientific models, emphasizing that their science is public and available for independent evaluation. He addresses concerns about the authenticity of customer reviews, explaining that due to HIPAA regulations, real patient names and images cannot be disclosed, and acknowledges the need to update their website to clarify the use of anonymized information. Sadeghi also highlights the evolving nature of genetic models, noting that updates are part of their commitment to providing accurate and up-to-date information to patients. (01:28:58) - Joe Weisenthal, born September 2, 1980, in Detroit, Michigan, is an American journalist and television presenter, currently serving as the executive editor of news for Bloomberg's digital brands and co-host of the "Odd Lots" podcast. In the conversation, he discusses the prolonged timeline before AI and robotics significantly impact sectors like elder care, referencing Honda's Asimo robot's initial promise to assist the elderly. He also addresses the shift in tech financing from venture capital to substantial debt, highlighting concerns over managing this debt and the implications of credit default swaps on major companies like Oracle. Additionally, Weisenthal critiques Nvidia's public responses to competitors, suggesting that confident companies typically avoid commenting on rivals, and reflects on Nvidia's rapid ascent from a successful chipmaker to one of the world's largest companies. (01:59:49) - Michael Kratsios, the 13th Director of the White House Office of Science and Technology Policy, discusses the Genesis Mission, a national initiative launched by President Trump to accelerate scientific discovery through artificial intelligence. He emphasizes the collaboration between national laboratories, universities, and tech companies to create a centralized digital platform that leverages federal scientific datasets, aiming to automate experiment design and significantly shorten discovery timelines. (02:26:28) - Sebastian Siemiatkowski, co-founder and CEO of Klarna, discusses the company's launch of KlarnaUSD, a U.S. dollar-backed stablecoin, marking a significant shift from his previous skepticism toward cryptocurrencies. He highlights that KlarnaUSD aims to reduce costs and increase efficiency in cross-border payments by leveraging the Tempo blockchain developed by Stripe and Paradigm. Siemiatkowski emphasizes that this initiative reflects Klarna's commitment to innovation and its ambition to challenge traditional payment networks by offering faster and more affordable services to consumers and merchants. (02:38:09) - David Faugno, CEO of 1Password, discusses the company's growth to over $400 million in annual recurring revenue, with nearly 80% of business coming from enterprise customers. He highlights 1Password's initiatives in AI integration, including partnerships with Perplexity's Comet browser and OpenAI's ChatGPT Atlas, to enhance secure usage of AI tools. Faugno also emphasizes the importance of credential hygiene in the face of increasing security threats and shares personal insights into his preference for fly fishing in Utah and Montana. (02:50:59) - Keller Rinaudo, co-founder and CEO of Zipline, announced a $150 million contract with the U.S. State Department to expand Zipline's autonomous drone delivery network across Africa, aiming to serve over 15,000 health facilities and reach an additional 130 million people. He highlighted the shift towards "Commercial Diplomacy," emphasizing partnerships that foster trade and technological collaboration rather than traditional aid. Rinaudo also discussed Zipline's rapid growth in the U.S., noting record-breaking delivery volumes and the transformative impact of their services on customer behavior and local economies. (03:08:11) - Royce Branning, co-founder and CEO of Clearspace, discusses the company's mission to help individuals reduce screen time by providing tools that enhance intentionality in technology use. He highlights the asymmetry in the battle for attention online and emphasizes equipping consumers with the ability to steer their focus and protect their family's attention. Branning also introduces Clearspace's new screen time agents that operate at the network layer, offering comprehensive visibility and control over device usage across all platforms. (03:19:18) - 𝕏 Timeline Reactions TBPN.com is made possible by: Ramp - https://ramp.comFigma - https://figma.comVanta - https://vanta.comLinear - https://linear.appEight Sleep - https://eightsleep.com/tbpnWander - https://wander.com/tbpnPublic - https://public.comAdQuick - https://adquick.comBezel - https://getbezel.com Numeral - https://www.numeralhq.comPolymarket - https://polymarket.comAttio - https://attio.com/tbpnFin - https://fin.ai/tbpnGraphite - https://graphite.devRestream - https://restream.ioProfound - https://tryprofound.comJulius AI - https://julius.aiturbopuffer - https://turbopuffer.comfal - https://fal.aiPrivy - https://www.privy.ioCognition - https://cognition.aiGemini - https://gemini.google.comFollow TBPN: https://TBPN.comhttps://x.com/tbpnhttps://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231https://podcasts.apple.com/us/podcast/technology-brothers/id1772360235https://www.youtube.com/@TBPNLive
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  • Reverse Engineering 200 AI Startups, Nucleus Genomics Controversy, Drone Hunting | Diet TBPN
    Our favorite moments from today's show, in under 30 minutes. TBPN.com is made possible by: Ramp - https://ramp.comFigma - https://figma.comVanta - https://vanta.comLinear - https://linear.appEight Sleep - https://eightsleep.com/tbpnWander - https://wander.com/tbpnPublic - https://public.comAdQuick - https://adquick.comBezel - https://getbezel.com Numeral - https://www.numeralhq.comPolymarket - https://polymarket.comAttio - https://attio.com/tbpnFin - https://fin.ai/tbpnGraphite - https://graphite.devRestream - https://restream.ioProfound - https://tryprofound.comJulius AI - https://julius.aiturbopuffer - https://turbopuffer.comfal - https://fal.aiPrivy - https://privy.ioCognition - https://cognition.aiGemini - https://gemini.google.comFollow TBPN: https://TBPN.comhttps://x.com/tbpnhttps://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231https://podcasts.apple.com/us/podcast/technology-brothers/id1772360235https://www.youtube.com/@TBPNLive
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  • Reviewing the Best AI Apps, Anthropic Unveils Claude 4.5 Opus, Doug DeMuro | Sholto Douglas, Quinn Slack, Alex Stauffer & Alex Shevchenko
    (02:06) - Reviewing the Best AI Apps (24:32) - 𝕏 Timeline Reactions (26:31) - Sholto Douglas, a Member of Technical Staff at Anthropic, discusses the launch of Claude Opus 4.5, highlighting its superior coding capabilities and efficiency in handling complex tasks. He emphasizes the model's advancements in vision understanding, particularly in interpreting front-end designs, while noting that generating images is not a current focus. Douglas also addresses the ongoing benefits of scaling in AI development, expressing confidence in continued progress and the potential for models to autonomously perform tasks with minimal human intervention. (01:00:44) - OpenAI Builds New Hardware Team with Jony Ive (01:05:00) - Timeline Reactions (01:31:48) - Doug DeMuro is an automotive YouTuber and entrepreneur known for his detailed, humorous car reviews and his signature “DougScore” rating system. He’s also the founder of Cars & Bids, an online auction platform focused on modern enthusiast vehicles. (02:26:11) - Alex Stauffer & Alex Shevchenko, Leads at Ramp Labs, discuss the development of Ramp Sheets, an AI-driven spreadsheet tool designed to enhance financial modeling and analysis. Initially an internal experiment to assist Ramp's finance team, the project evolved into a public web-based platform, allowing users to quickly create models without replacing existing tools like Excel. Since its recent launch, Ramp Sheets has gained significant traction, with thousands of users daily, including students, professors, and professionals across various industries. (02:36:00) - Quinn Slack, CEO and co-founder of Amp & Sourcegraph, discusses the integration of advertisements into their AI coding agent, Amp, to offer it for free while offsetting operational costs. He highlights the unique opportunity to display targeted ads within the coding environment, leveraging developers' continuous engagement with the tool. Slack also emphasizes the potential for partnerships and the importance of balancing ad integration with user experience to advance AI adoption in coding. (02:48:34) - 𝕏 Timeline Reactions TBPN.com is made possible by: Ramp - https://ramp.comFigma - https://figma.comVanta - https://vanta.comLinear - https://linear.appEight Sleep - https://eightsleep.com/tbpnWander - https://wander.com/tbpnPublic - https://public.comAdQuick - https://adquick.comBezel - https://getbezel.com Numeral - https://www.numeralhq.comPolymarket - https://polymarket.comAttio - https://attio.com/tbpnFin - https://fin.ai/tbpnGraphite - https://graphite.devRestream - https://restream.ioProfound - https://tryprofound.comJulius AI - https://julius.aiturbopuffer - https://turbopuffer.comfal - https://fal.aiPrivy - https://www.privy.ioCognition - https://cognition.aiGemini - https://gemini.google.comFollow TBPN: https://TBPN.comhttps://x.com/tbpnhttps://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231https://podcasts.apple.com/us/podcast/technology-brothers/id1772360235https://www.youtube.com/@TBPNLive
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  • The State of AI: A Field Trip to TBPN’s Aura Farm + Today’s Top Tech Stories | Diet TBPN
    Diet TBPN delivers the best of today’s TBPN episode in under 30 minutes. TBPN is a live tech talk show hosted by John Coogan and Jordi Hays, streaming weekdays 11–2 PT on X and YouTube, with each episode posted to podcast platforms right after. Described by The New York Times as “Silicon Valley’s newest obsession,” the show has recently featured Mark Zuckerberg, Sam Altman, Mark Cuban, and Satya Nadella.TBPN.com is made possible by:Ramp - https://ramp.comFigma - https://figma.comVanta - https://vanta.comLinear - https://linear.appEight Sleep - https://eightsleep.com/tbpnWander - https://wander.com/tbpnPublic - https://public.comAdQuick - https://adquick.comBezel - https://getbezel.com Numeral - https://www.numeralhq.comPolymarket - https://polymarket.comAttio - https://attio.com/tbpnFin - https://fin.ai/tbpnGraphite - https://graphite.devRestream - https://restream.ioProfound - https://tryprofound.comJulius AI - https://julius.aiturbopuffer - https://turbopuffer.comfal - https://fal.aiPrivy - https://www.privy.ioCognition - https://cognition.aiGemini - https://gemini.google.comFollow TBPN: https://TBPN.comhttps://x.com/tbpnhttps://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231https://podcasts.apple.com/us/podcast/technology-brothers/id1772360235https://www.youtube.com/@TBPNLive
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Technology's daily show (formerly the Technology Brothers Podcast). Streaming live on X and YouTube from 11 - 2 PM PST Monday - Friday. Available on X, Apple, Spotify, and YouTube.
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