Plain English with Derek Thompson

Dramatic regime change. Moderate regime evolution. A calamitous regional conflict. Or … no change at all. Today we consider how the Iran conflict might evolve following the killing of Supreme Leader Khamenei with Karim Sadjadpour, an American policy analyst at the Carnegie Endowment for International Peace.

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Host: Derek ThompsonGuest: Karim SadjadpourProducer: Devon Baroldi
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The modern world swims in numbers: work metrics, fitness metrics, health metrics, social media metrics. Sometimes the quantification of life can make things better. But very often, I think they force us to play the games we can measure rather than the games we value. The quantified life has become a modern religion: a system of values that takes us over and keeps us from living the life we want.

Today’s guest is the philosopher C. Thi Nguyen. He is the author of the book The Score: How to Stop Playing Somebody Else's Game. We talk about metrics, the games of life, and how to listen to the parts of ourselves that cannot be reduced to numbers.

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If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson

Guest: C. Thi Nguyen

Producer: Devon Baroldi
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The GLP-1 drug revolution has taken the medicine world by storm. I’ve done several episodes on the science of GLP-1s. But we’ve never done an episode like this before, where we talk to one of the most important people in charge of guiding the GLP-1 drug revolution.

Our guest is Dave Ricks, the CEO of Eli Lilly, the largest pharmaceutical company in the world. First we talk about what makes the GLP-1 drug category special and the science that Lilly is doing to improve these drugs. Then, we talk about the pharmaceutical industry more broadly. How it works. How it could work better. And I don’t shy away from the question that I think Pharma CEOs need to take much more seriously: If the pharmaceutical industry is theoretically more devoted than any other economic category to saving people’s lives, why do Americans distrust it more than any other industry in the entire economy?

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Host: Derek ThompsonGuest: David RicksProducer: Devon Baroldi
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Donald Trump suffered a huge blow Friday when the Supreme Court struck down the centerpiece of his economic policy: his vast system of tariffs. So, what happens now? Harvard’s Jason Furman explains the implications for the U.S. economy, consumers, global trade, and Trump’s strategy of centralizing power in the executive branch and using trade policy as a means of wringing concessions out of other counties.

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If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek ThompsonGuest: Jason FurmanProducer: Devon Baroldi
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In the mid-20th century, a group of media and communications scholars proposed that the shift from spoken to written language—from orality to literacy—transformed our politics, our media, our social relations, and even our sense of consciousness. Today we’re undergoing another shift: from a literate culture to something stranger—a post-literate world awash in social media and digital communications in which oral traditions are making a comeback. Bloomberg’s Joe Weisenthal, the cohost of the Odd Lots podcast, has called this one of the most important trends in the world. Today he explains how he got hooked on orality theory and why it’s the skeleton key that unlocks so many oddities of the modern world.

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If you have questions, observations, or ideas for future episodes, email us at [email protected].

Host: Derek Thompson

Guest: Joe Weisenthal

Producer: Devon Baroldi
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