Manchin & Sinema detail key disagreements over Biden agenda; One-on-one with White House press secretary Jen Psaki; CNN Poll: only 25% of Americans see economic bills helping them; Klain retweets economist saying inflation is a “high class” problem; Psaki’s mention of VA governor’s race raises objections; FDA panel recommends J&J booster 2 months after first shot; CDC: unvaccinated adults have 11x higher risk of dying, 6x higher chance of testing positive; CDC: more than 90% of people who got J&J may be eligible for booster; NIH study: mixing & matching boosters seems effective; Migrant surge complicating VP Harris’s border assignment; DHS watchdog report criticizes ICE’s use of solitary confinement; Bill Clinton in hospital aster infection spread to bloodstream; Bill Clinton hospitalized for infection but “on the mend”; Source: Biden called Clinton, talked politics & VA gov race; British lawmaker stabbed to death at meeting with voters; British counter-terrorism police to lead investigation into stabbing death of member of British parliament; To learn more about how CNN protects listener privacy, visit cnn.com/privacy

FDA vaccine panel will consider J&J boosters on Friday; Sources: WH vetting former FDA chief to run agency again; FDA vaccine panels votes to recommend Moderna Covid booster; Vermont Covid cases surge, despite highest vaccination rate in U.S.; PA state lawmaker’s key role in run-up to insurrection; 10,000 John Deere workers go on strike after rejecting deal; Jan. 6 committee pursues criminal contempt referral for Bannon; Workers striking across U.S. as labor shortage leaves some employees without much leverage; Trump becomes central figure in upcoming Virginia election; Trump keeps up the big lie, says Republicans will not vote in 2022 or 2024 if “fraud” is not solved; Murdaugh charged with stealing money from housekeeper’s sons To learn more about how CNN protects listener privacy, visit cnn.com/privacy

U.S. will open Canadian, Mexican borders to vaccinated travelers; TSA: Passengers bringing guns to airports at unprecedented levels; UNC chancellor declares “mental health crisis” on campus; Shatner, Blue Origin crew complete historic space trip To learn more about how CNN protects listener privacy, visit cnn.com/privacy

CNN: autopsy reveals Gabby Petito died by “manual” strangulation; Laundrie family attorney reacts to cause of death, says “death at such a young age is a tragedy”; Coroner: state stature says only cause of death, manner will be released; Coroner: Petito’s body was outside in the wilderness for 3-4 weeks before being found; Pelosi: “very disappointed” democrats could not reach deal on original $3.5T spending package; Biden poll numbers drop amid COVID, economic crisis; Judge: NY heath care workers can claim religious exemption; NY Nets star can’t play until he is fully vaccinated; Poll: 65% support vaccine mandates for health care workers; Dr. Fauci: “we know that mandates work”; Mom files lawsuit, calls schools a COVID-19 “snake pit”; Mother of 10-year-old who dies: “COVID is not over”; Buenos Aires begins vaccinating children at age 3; New U.S. OVID cases at lowest point since early August; American & Southwest Airlines keeping mandates for employee vaccinations despite Texas governor’s order; Schiff calls McCarthy an “insurrectionist in a suit and tie”; Schiff vows quick action if Trump insiders defy subpoenas; Senate report details FOP Rep Scott Perry’s role in Trump’s plot to overturn election; Gas prices skyrocket to highest levels in seven years; AAA: national average for gas hits $3.28 a gallon, up 20 cents in a month; To learn more about how CNN protects listener privacy, visit cnn.com/privacy

Merck: COVID pill cut risk of hospitalization & death by 50%; COVID cases & hospitalizations drop in U. S. as vaccinations rise; FDA vaccine advisers meet this week to discuss booster shots from Moderna, Johnson & Johnson; Dr. Fauci: “go out there” and enjoy Halloween; GOP candidate for governor in Texas: COVID vaccine is a “dangerous shot”; Pushes for more antibody treatments; Labor dept: heath care industry lost more than 500,000 employees since February 2020; Trump allies get subpoenaed, as committee threatens to pursue criminal charges for those who don’t comply; Capitol police whistleblower alleges leadership failures on Jan 6; No. 2 house republican dodges on whether 2020 election “stolen”; Cheney calls out Scalise for refusing to say Biden won election; Trump sends birthday video demanding “justice” for capitol rioter Ashli Babbitt over 1/6 death; Grassley embraces Trump’s support as former pres. spreads lies; Taliban preaches gentler approach; but violence, oppression are reality; CNN on the ground in Taliban controlled Afghanistan; Afghan says Taliban “were enjoying beating me”; FBI: couple tried to sell nuclear intel hidden in sandwich; Southwest cancels hundreds of flights for fourth straight day; Southwest blames air traffic control problems, staff shortages and weather for cancellations; Passengers stranded as Southwest cancels thousands of flights; To learn more about how CNN protects listener privacy, visit cnn.com/privacy