
Constipation, Microbiome, and Parkinson's: Unraveling the Gut's Role in Neurodegeneration
17/12/2025 | 36 min
Welcome to another episode of The Caring Neurologist! Today, host Dr. Sandeep Thakkar dives into a truly fascinating topic that’s changing the way we think about Parkinson’s disease. When most people hear “Parkinson’s,” they picture tremors and movement challenges. But what if the earliest warning signs of this brain disorder actually begin in the gut?In this episode, Dr. Sandeep Thakkar unravels the intricate connection between our digestive system and brain health. They discuss how early symptoms like constipation, gut inflammation, and changes in the microbiome might signal Parkinson’s long before the first tremor appears. You’ll learn about the vital role of the vagus nerve, the mysterious behavior of the alpha synuclein protein, and the potential for future diagnostics that could detect Parkinson’s through a simple gut test.Whether you’re living with Parkinson’s, caring for someone who is, or simply curious about how the body and brain communicate, this episode will leave you with new insights and maybe some hope about the future of prevention and early intervention in neurological disease. So grab your headphones, settle in, and get ready to discover why your next healthy choice could start with your gut!00:00 Gut-Brain Link in Parkinson's04:43 Gut-Brain Connection and Coordination07:25 Gut Health and Mental Clarity10:04 Gut-Brain Axis: Cause or Effect?14:05 Vagus Nerve's Role in Parkinson's19:59 "Gut Health and Brain Connection"20:53 Gut Health and Microbiome Research24:15 "Parkinson’s Diagnosis via Gut Biomarkers"27:38 Diet's Role in Gut Health31:26 Oral Bacteria's Link to Disease33:51 Parkinson's: Gut Health MattersThe Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/ “Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

The Evolution of Levodopa: From Ancient Remedies to Cutting-Edge Parkinson’s Care
02/12/2025 | 28 min
Welcome back to The Caring Neurologist, where science, stories, and breakthrough discoveries meet compassionate care. In today’s episode, host Dr. Sandeep Thakkar takes you on a deep dive into the fascinating journey of Levodopa, the drug that transformed Parkinson’s treatment and remains the gold standard decades after its introduction. From its ancient roots in Ayurvedic medicine to the groundbreaking trials that redefined patient care, you’ll learn how Levodopa works, why it’s so effective, and what the latest innovations in delivery systems mean for the future. Whether you’re a patient, caregiver, or just curious about neurological breakthroughs, this episode promises practical insights, myth-busting moments, and a renewed sense of hope for those navigating life with Parkinson’s.00:00 "Levodopa: History and Significance"04:38 Improved Levodopa Delivery Options09:52 Levodopa vs Dopamine Agonists13:37 Levodopa: Debunking Longevity Myths16:32 Assessing Quality of Life in Parkinson's19:03 "Protein-Rich Meals Impact Medication"23:05 Advancements in Levodopa Therapies25:42 "Learning Prevents Cognitive Decline"28:35 Levodopa: Key in Parkinson's CareThe Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/ “Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Reimagining Parkinson's Care: Dr. Thakkar's Vision for a True Multidisciplinary Center of Excellence
05/10/2025 | 49 min
Welcome back to The Caring Neurologist, where science meets storytelling and every conversation brings us closer to better care. In this episode, Dr. Sandeep Thakkar pulls back the curtain on a transformative vision for Parkinson’s and movement disorder care - a vision that challenges the outdated, fragmented healthcare system and reimagines what true, patient-centered excellence should look like.You’ll hear Dr. Thakkar’s bold blueprint for a Center of Excellence: an integrated space where patients access everything from advanced clinical care and cutting-edge research, to on-site physical and speech therapy, nutrition consultations, mental health support, wearables, and even real-time technology solutions - all under one roof. We’ll dive deep into the frustrations patients and their families face navigating the system, the gaps in access and coordination, and why innovation in research and technology can’t wait another decade to reach people who need it most. If you’ve ever wondered what’s possible when we stop settling for the status quo - and how multidisciplinary, tech-enabled, compassionate care could revolutionize the patient experience - this episode is for you. Whether you’re a patient, caregiver, clinician, or someone who believes in progress, you won’t want to miss this inspiring discussion about building a better future for neurological care.Timestamps:00:00 Integrated Community Parkinson's Care06:56 Comprehensive Care for Chronic Illnesses08:24 Healthcare Access Without Limitations11:09 Accessible Healthcare for All Patients17:00 "Sensor Technology in Healthcare Monitoring"18:08 Innovative Clinical Data Collection23:58 Vision for a 21st Century Healthcare27:06 Apple Watch Alerts Parkinson's Risk31:25 Telemedicine Expansion in Healthcare34:58 Comprehensive Health Clinic Vision36:32 Expanding Parkinson's Research Network39:32 Supportive Patient Inspires Podcast Efforts43:38 Advocate in Healthcare and Research48:02 "Visionary Healthcare: Building the Future"The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/ “Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Movement is Medicine: How Exercise Transforms Parkinson’s Care and Quality of Life
29/9/2025 | 39 min
Welcome back to The Caring Neurologist! In this energizing episode, lucky number 13, host Dr. Sandeep Thakkar for a deep dive into one of the hottest topics in Parkinson’s care: movement as medicine. Together, they explore how exercise is not just symptom management, but an active tool in reshaping the progression and daily experience of Parkinson’s disease.Dr. Thakkar shares the latest research about the brain-boosting powers of movement, from increasing dopamine and neurotrophic factors to helping regulate mood, sleep, and even digestion. Whether you’re newly diagnosed, a caregiver, or just looking to boost your neural health, you’ll come away with practical tips for building a balanced exercise routine tailored to your stage of Parkinson’s and abilities. Plus, you’ll hear real patient stories that prove it’s never too late to get moving, be it through dance, boxing, or even picking up juggling for the first time.So if you’re curious about whether consistency or intensity matters most, if you want advice on starting safely, or if you’re just seeking a bit of motivation, this episode is packed with insights, humor, and inspiration to help you—and those you love, keep moving forward.00:00 Healthcare Insights: Focus on Exercise04:03 Parkinson's: Stretching and Balance Essentials07:45 Exercise Boosts Brain Health10:10 Holistic Exercise for Parkinson's Care12:51 Essential Strength Training with Pilates17:01 Improving Mobility and Coordination Techniques21:58 Coordinated Exercise Benefits23:32 Holistic Exercise for Wellness26:17 Balanced Daily Exercise Routine28:59 Parkinson's: High-Intensity Exercise Benefits34:48 Future Book Plans: Patient Success Stories38:15 Exercise Revives Sex Life for Seniors39:02 Maximize Life, Stay ActiveThe Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/ “Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Hormones, Symptoms, and Support: What We’re Missing About Women with Parkinson’s
15/9/2025 | 41 min
Welcome back to The Caring Neurologist! In today’s episode, host Dr. Sandeep Thakkar dives deep into a topic too often overlooked: the unique challenges women face with Parkinson’s disease. Although Parkinson’s is typically studied and portrayed as affecting everyone similarly often depicted as an older man with hallmark symptoms today’s conversation unpacks why that perspective misses the mark for women, and what important gaps remain in our understanding, diagnosis, and treatment of Parkinson’s in female patients.Dr. Thakkar explores how hormones like estrogen impact risk and progression, why women are often diagnosed later than men, and how symptom presentation, side effects, and even clinical research representation differ between the sexes. They also talk candidly about the emotional, psychological, and caregiving burdens unique to women living with Parkinson’s, and discuss actionable steps for doctors, advocates, and patients to move toward more gender-aware care.If you’re curious about the science, the lived experience, and what the future of Parkinson’s care could look like for women, this episode is not to be missed. Let’s get started!00:00 Parkinson's Misrepresentation in Research05:49 Gender-Neutral Healthcare Challenges07:19 Gender Disparities in Health Care12:08 Estrogen's Protective Role in Parkinson's16:07 Gender Differences in Disease Progression17:52 Misdiagnosed Health Struggles22:18 Women's Health & Environmental Risks27:00 Gender Differences in Treatment Response27:52 Addressing Gender Bias in Research32:29 Personalized Neurotransmitter Therapy for Women36:01 Gender Differences in Disease Experience40:01 Exploring Hormonal Therapies' Future41:01 Anticipating Episode 13The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/ “Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”



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